1235 CARNITINE ACYLTRANSFERACE II: INHIBITION BY KREBS CYCLE INTERMEDIATES
نویسندگان
چکیده
منابع مشابه
Sodium-coupled transporters for Krebs cycle intermediates.
Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate are transferred across plasma membranes of cells by secondary active transporters that couple the downhill movement of sodium to the concentrative uptake of substrate. Several transporters have been identified in isolated membrane vesicles and cells based on their functional properties, suggesting the existence of at ...
متن کاملEffect of streptolysin O on the utilization of some Krebs cycle intermediates by Aerobacter aerogenes.
A preparation of streptolysin 0 partially purified from Streptococcus pyogenes strain C203S was shown to contain at least two distinct entities (Carlson et al., 1956): streptolysin 0 which brings about a marked loss of myocardial contractile power in isolated, perfused guinea pig, rabbit, and rat hearts (Kellner et al., 1956), and a diphosphopyridine nucleotidase which specifically attacks diph...
متن کاملEffect of Streptolysin 0 on the Utilization of Some Krebs Cycle Intermediates by Aerobacter Aerogenes Sue
A preparation of streptolysin 0 partially purified from Streptococcus pyogenes strain C203S was shown to contain at least two distinct entities (Carlson et al., 1956): streptolysin 0 which brings about a marked loss of myocardial contractile power in isolated, perfused guinea pig, rabbit, and rat hearts (Kellner et al., 1956), and a diphosphopyridine nucleotidase which specifically attacks diph...
متن کاملMalonate inhibition of oxidations in the Krebs tricarboxylic acid cycle.
The inhibition of succinate oxidation by malonate is a well known phenomenon. Since the oxidation of succinate to fumarate is an integral part of the Krebs cycle of oxidations, it has been generally assumed that the inhibitory effect of malonate upon the oxidation of any member of the cycle is the result of the inhibition of the succinate to fumarate step. However, the present paper provides ev...
متن کاملThe life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.
A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test wheth...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-01265